For the most complete analysis of the evidence for Omega 3 (and other miconutrients) the very best resource I've found is Dr Rhonda Patrick: https://www.foundmyfitness.com/topics/omega-3
The academic paper this story is based on is here: https://nature.com/articles/s43587-024-00793-y
Despite the linked story title only mentioning omega3, the paper was about 3 interventions, that, vitamin D, exercise and found reduced epigenetic age from the interventionts, with bigger anti-aging benefit as they were combined.
With respect to vitamin D specifically, this isn't by itself good evidence vitamin D reverses aging. But it is consistent with the totality of evidence that being vitamin D deficient probably (causally) speeds aging. And it mildly increases the overall weight of evidence of a connection.
As with much vitamin D research, it would have been better for the intervention to have been titrate vitamin D supplement amount to achieve an optimal target range (eg 30-60ng/ml) rather than using a fixed relative moderate dose (2000IU).
The problem with a fixed dose is that surely some subjects started severely deficient, some mildly, and some had sufficient levels. The moderate but not very high fixed dose will have helped many in the middle group climb out of deficiency, not been enough for many in the 1st group to bring them fully out of deficiency, and been unnecessary for those in the 3rd group, so the study ends up seeing a weaker overall effect averaged over all subjects. This is well known within the vitamin D world, eg see https://x.com/KarlPfleger/status/1732514710715514883, but somehow has not permeated to be widely enough understood, even within the scientific community (or the Hacker News community).
The yellow kind of Omega-3 comes from salmon, and it has a side effects of making a stink and also concentrating mercury.
Instead, you should get your omega-3 from krill oil, which is low on the food chain does not concentrate Mercury is all around better
For the most complete analysis of the evidence for Omega 3 (and other miconutrients) the very best resource I've found is Dr Rhonda Patrick: https://www.foundmyfitness.com/topics/omega-3
But: https://pmc.ncbi.nlm.nih.gov/articles/PMC10175873/
The academic paper this story is based on is here: https://nature.com/articles/s43587-024-00793-y Despite the linked story title only mentioning omega3, the paper was about 3 interventions, that, vitamin D, exercise and found reduced epigenetic age from the interventionts, with bigger anti-aging benefit as they were combined.
With respect to vitamin D specifically, this isn't by itself good evidence vitamin D reverses aging. But it is consistent with the totality of evidence that being vitamin D deficient probably (causally) speeds aging. And it mildly increases the overall weight of evidence of a connection.
As with much vitamin D research, it would have been better for the intervention to have been titrate vitamin D supplement amount to achieve an optimal target range (eg 30-60ng/ml) rather than using a fixed relative moderate dose (2000IU).
The problem with a fixed dose is that surely some subjects started severely deficient, some mildly, and some had sufficient levels. The moderate but not very high fixed dose will have helped many in the middle group climb out of deficiency, not been enough for many in the 1st group to bring them fully out of deficiency, and been unnecessary for those in the 3rd group, so the study ends up seeing a weaker overall effect averaged over all subjects. This is well known within the vitamin D world, eg see https://x.com/KarlPfleger/status/1732514710715514883, but somehow has not permeated to be widely enough understood, even within the scientific community (or the Hacker News community).
For an extensive list of papers supporting a link between vitamin D and speed of aging, see https://x.com/KarlPfleger/status/1390717755158974464
This may explain why people who use the Mediterranean diet tend to live long, healthy lives.
https://elicit.com/review/c701554b-5722-424d-a3d7-b805b5878a...
How do they separate the impact of the 3x per week exercise?
Yep, I haven't aged a day for last 10 years. :)
Opposing claims?
"Vitamin D3 and omega-3 fatty acids not helpful in reducing risk of frailty" https://medicalxpress.com/news/2022-09-vitamin-d3-omega-fatt...